HPLC-DAD analysis and antifungal effect of Hyptis martiusii Benth (Lamiaceae) against Candida strains
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Cytotoxic abietane diterpenes from Hyptis martiusii Benth.
From roots of Hyptis martiusii Benth. two tanshinone diterpenes were isolated, the new 7beta-hydroxy-11,14-dioxoabieta-8,12-diene (1) in addition to the known 7alpha-acetoxy-12-hydroxy-11,14-dioxoabieta-8,12-diene (7alpha-acetoxyroyleanone) (2). Structures of 1 and 2 were established by spectroscopic means. The cytotoxic activity against five cancer cell lines was evaluated. Compounds 1 and 2 d...
متن کاملRepeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice
Hyptis martiusii Benth. (Lamiaceae) is found in abundance in Northeastern Brazil where it is used in traditional medicine to treat gastric disorders. Since there are no studies reporting the toxicity and safety profile of this species, we investigated repeated-doses toxicity of the essential oil of Hyptis martiusii (EOHM). Swiss mice of both sexes were orally treated with EOHM (100 and 500 mg/k...
متن کاملIn vitro interference of Hyptis martiusii Benth. & chlorpromazine against an aminoglycoside-resistant Escherichia coli.
The antibacterial and synergistic activity of the ethanol extract from Hyptis martiusii Benth. was assayed by microdillution. The growth of two isolates of Escherichia coli tested was inhibited by the extract. The minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) values ranged from 512 and >1024 microg/ml for the E. coli 27 and 1024 and > 1024 microg/ml for the E. coli AT...
متن کاملChemical Composition, Modulatory Bacterial Resistance and Antimicrobial Activity of Essential Oil the Hyptis martiusii Benth by Direct and Gaseous Contact
BACKGROUND Several studies have shown that species of the genus Hyptis, have promising antimicrobial and antifungal effects. OBJECTIVES Identify of chemical constituents of essential oil from leaves of Hyptis martiusii and evaluate its effect against bacterial strains by direct and gaseous contact. MATERIALS AND METHODS Essential oil was extracted from leaves of Hyptis martiusii Benth using...
متن کاملAntifungal Effect of Echinophora Platyloba' s Extract against Candida albicans
The present study was undertaken to investigate the effectiveness of the ethanolic extract of Echinophora platyloba DC. on Candida albicans. Using the agar dilution method, the growth condition of standard Candida albicans ATCC 10231, cultured on the media containing plant extracts at different concentrations (1,2,4,8,16,32,64,128 and 256 mg/ml) was studied. The results were recorded twenty one...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Biomedicine
سال: 2019
ISSN: 2221-1691
DOI: 10.4103/2221-1691.254606